Why does IVF fail with good embryos?

Summary:  It is usually the quality of the embryo which defines the success of the IVF procedure over and above the other physical factors involved. The receptivity of the uterus lining is also important and plays an important role in the IVF success. 


IVF failure can be very devastating for any couple. The most difficult question for any doctor to answer is why the IVF procedure failed with a good embryo. Through there is no particular reason that the doctors can specifically pin point for the failure, but there are several factors that could collectively be responsible for it.

The quality of the embryo plays a vital role in the success of the IVF procedure. But when an IVF procedure fails with a good quality embryo then it is time to look into the other areas that support implantation and a successful pregnancy. There are a number of other factors that play an important role in a successful implantation such as the lifestyle of the mother, the health of the mother, the receptivity of the uterine lining, to name a few.

The mother needs to adhere to certain precautionary measures after the IVF transfer which includes not over exerting physically. Some women are not consciously aware of the restrictions and this causes the IVF to fail.

Uterine lining receptivity is very essential for the success of an IVF transfer. When the uterine lining is receptive the embryo will implant successfully. This is one reason why the blastocyst transfer is becoming increasingly popular and appears to have a much higher success rate. This procedure means that the embryo is transferred to the uterus after 5 or 6 days of fertilisation. In a natural pregnancy the fertilised embryo takes several days to reach the uterus and in the meanwhile the uterus lining thickens and prepares itself for the embryo. The blastocyst transfer matches this timing very closely and is at the peak of its receptivity.

Not always does the IVF fail due to the uterus. Embryos are selected based on the way they appear and their development after fertilisation. Quite often an embryo that looks good may have a weakness or an abnormality which causes the embryo either not to implant or to die. More often the IVF failure is due to the quality of the embryo rather than the uterus receptivity or other factors.

Some FAQ’s

Q: I have had 4 IVF failures, is there any alternative option for me?

A: It depends on the cause of your IVF failure. You could ask your doctor about blastocyst transfer as it has a higher pregnancy success rate.

Q: My doctor says I have unexplained fertility. I tried IVF treatment, but it failed. How can I get pregnant?

A: A thorough medical check-up with ultrasound of your reproductive organs can help the doctor to determine where the problem might be.

Q: We have good embryos but I seem to have some problem with my uterus because of which my IVF failed twice. What can I do to improve the condition of my uterus?

A: It is difficult to tell without any test reports or a proper diagnosis. However, you could give your uterus a rest for a few months and in the mean while eat a nutritious diet and adopt a regular exercise regime. It helps the blood circulation and improves the health of your uterus.

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